Antacids containing aluminum, cal-cium, magnesium; laxatives containing magnesium: Decreased oral absorption of minocycline. Give antibiotic 1 hour before or 2 hours after these drugs.
Digoxin: Increased bioavailability. Monitor serum digoxin levels; adjust dosage as needed.
Oral anticoagulants: Enhanced anticoagulant ef-fects. Monitor PT and INR; adjust dosage as nec-essary.
Oral contraceptives: May be less effective when administered with minocycline. Recommend use of nonhormonal birth control.
Oral iron products, sodium bicarbonate: De-creased absorption. Give drug 2 hours before or ' 3 hours after iron administration.
Penicillin: Tetracyclines may antagonize bacteri-cidal effects. Administer penicillin 2 to 3 hours be-fore minocycline.
Drug-food.
Any food, milk, other dairy products: Decreased absorption of minocycline. Advise child to take drug with full glass of water.
Drug-lifestyle.
Sun exposure: Increased risk of photosensitivity reactions. Tell child to take
pre-cautions. |